2019 CPIP-C Case 3: Molecular Genetics/Lab Management: Needle in a Haystack – Diagnosis of Genetic Mosaicism Driving Somatic Overgrowth


Learn the presentation and causative mutations for segmental overgrowth conditions and understand the laboratory director’s consultative role in guiding selection of both an appropriate test and a high-quality CLIA-certified laboratory to obtain an accurate diagnosis.

Credit Type: CME, SAM, CPD
Duration: 1 hour 15 minutes
Launch Date: March 18, 2019
Expiration Date: March 17, 2022 12:00 AM (ET)
Pricing: Member Fee: $45.00 Nonmember Fee: $59.00 Junior Member Fee: $10.00
MOC Category: Medical Knowledge, Patient Care

Registration Information
To register for this activity, you must either pay by credit card or have ordered this product in advance. Click the Register button to continue, and you will be prompted for validation or processed for payment.

To enroll in the series with one easy payment, or to enroll multiple participants from the same institution, contact the CAP at 800-323-4040 option 1. This option is only available until December 31, 2019, after this date this activity is only accessible by an online credit card payment.

Description
Highly sensitive next generation sequencing-based assays have driven a rapid expansion of gene-disease associations for a diverse group of segmental overgrowth syndromes, highlighted by Proteus and PIK3CA-related overgrowth syndromes. The diagnostic yield may be as high as 70% but requires selection of the appropriate assay and performing laboratory.

This clinical pathology activity is intended for pathologists and residents.

Objectives
After completing this SAM eligible activity and post-test, you should be able to:

  1. Recognize the clinical presentations of somatic overgrowth syndromes.
  2. Associate the diagnostic subgroups of somatic overgrowth with the causative mutations in characterized genes and biochemical pathways.
  3. Apply general considerations for selection of reference laboratories as required for CAP accreditation.
  4. Apply specific assay performance criteria required for genetic testing in suspected cases of mosaicism such as somatic overgrowth conditions.
  5. Recognize the potential clinical utility of genetic testing for somatic overgrowth conditions and emerging treatment options.

Related Link
Clinical Pathology Improvement Program

CME Information
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This activity meets the American Board of Pathology’s (ABP) Continuing Certification (CC) requirements for Self-Assessment Modules (SAMs).

Continuing Professional Development (CPD), Section 3 Credit
Accreditation in Canada: This event is an Accredited Self Assessment Program (Section 3) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada, approved by the Canadian Association of Pathologists - Association Canadienne des Pathologistes. You may claim a maximum of 1.25 hours equivalent to 3.75 credits.

Passing Requirements
You have a total of three opportunities to take and pass the post-test. If you correctly answer 70% or more of the post-test items, you may claim credit. CME/SAM credit can be applied to the American Board of Pathology (ABP) Self-Assessment Module (SAM) requirements. You must pass the post-test to claim credit; therefore, if you do not pass, you cannot claim any credit.

Attention Canadian Participants: You have three opportunities to take and pass the post-test. If you do not pass the post-test after three attempts, you may still claim CPD credit (self-assessment program credits) for this activity. Please contact a representative of the CAP Learning Division at 800-323-4040 option 1 or education@cap.org with the name of this activity and the date completed to request a letter of participation.

Payment Information
To pay with a check, print a copy of this page and send it with your check to the address below. You will be notified when your payment has been processed and you have been registered into the activity.

College of American Pathologists
Education Division
325 Waukegan Road
Northfield, IL 60093-2750

Refund Policy
Refunds will be handled on an exception basis. Please submit your request to the CAP in writing via email at education@cap.org or fax at 847-832-8006.

Technical Requirements
Pop-up blockers must be turned off.

CAP Learning has recognized that some Veteran’s Administration, US Government, and military participants may have difficulty accessing the online assessment portion of this activity. If you experience difficulty or have any questions, please contact a representative of the CAP Learning Division at 800-323-4040 option 1 or education@cap.org.

Availability
This activity and evaluation is available March 18, 2019, and will expire on March 17, 2022, at 12:00 AM (ET). You MUST claim credit by this date and time.

CC: CPIP0303Q.2019



Type:     Internet Activity (Enduring Material)
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